Natural Factors SAMe 200 mg 60 Enteric Coated Tablets


Natural Factors SAMe provides a direct source of S-adenosyl-L-methionine, a naturally occurring compound found in every cell in the body. SAMe helps support mood balance through the synthesis of serotonin, dopamine, and phosphatidylserine, important mood-balancing compounds. It also helps relieve joint pain caused by osteoarthritis and contributes to numerous metabolic processes. This dual-action formula comes in easy-to-swallow, enteric-coated tablets that enhance its absorption and stability.

Uses & Benefits
  • Supports healthy mood balance
  • Helps relieve the pain of osteoarthritis
  • Used to raise serotonin, dopamine, and phosphatidylserine levels
  • Assists with the production of sulfur compounds needed for healthy joint cartilage
Recommended Use
  • Helps support healthy mood balance and relieve osteoarthritic pain.
Recommended Dose

SAMe should always be taken an emnty stomach SAMe must he taken for a minimum of 2 weeks, at which time effects should be observed. For mood balance: 1-4 tablets 2 times daily (up to 8 tablets daily) or as directed by a health care practitioner. Consult a health care practitioner for use beyond 6 weeks. For osteoarthritic pain: 2 tablets 3 times daily, not to exceed 6 tablets daily, or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.


Consult a health care practitioner prior to taking SAMe if you are taking anti-depressants, hepatotoxic drugs, or monoamine oxidase (MAO) inhibitors. Not recommended for use in children. Do not use if you are pregnant or breastfeeding or if you have bipolar disorder (manic-depressive illness). Do not take at night as SAMe may cause anxiety, restlessness, and insomnia. Possible side effects are mild gastrointestinal upsets (such as stomach pain, nausea, diarrhea, and flatulence), anxiety, hyperactive muscle movement, insomnia, and hypomania. When these side effects occur, they often diminish with time or resolve with lower doses or cessation of use. Keep out of the reach of children.

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Natural Factors SAMe is a mood and joint support supplement featuring the naturally occurring compound S-adenosylmethionine (SAMe). SAMe is found in every cell of the body where it is the principal methyl donor needed for numerous metabolic processes.

SAMe helps raise the body’s production of the mood-balancing compounds serotonin, dopamine, and phosphatidylserine. Serotonin and dopamine are chemical messengers with important roles in mood and behaviour, while phosphatidylserine is a key phospholipid found in the membranes of brain cells. Supplementing with SAMe also helps relieve painful osteoarthritis symptoms by maintaining cartilage health and contributing to the production of joint-supporting compounds, such as glucosamine and chondroitin.

Natural Factors SAMe 200 mg features enteric-coated tablets that are easy to swallow and remain stable during digestion for maximum bioavailability. It provides the same form of SAMe used in clinical studies and is a great option for older adults who experience low mood or joint pain caused by osteoarthritis. This product might not be suitable for people already taking prescription antidepressants or who have bipolar disorder. Always read the label cautions before use.

Each tablet contains:
S-adenosyl-L-methionine (SAMe) 200 mg
(from 400 mg of S-adenosyl-L-methionine disulfate tosylate)

Additional information

Weight 56 kg
Dimensions 5.6 × 5.6 × 9.9 cm